Research publications (More references in the members section)

2023

Mahmoud O, Oladipo O, Mahmoud RH, Yosipovitch G. Itch: from the skin to the brain - peripheral and central neural sensitization in chronic itch. Front Mol Neurosci 2023:16:1272230. doi: 10.3389/fnmol.2023.1272230
https://www.frontiersin.org/articles/10.3389/fnmol.2023.1272230/full

2022

Sutaria N, Adawi W, Goldberg R, Roh YS, Choi J, Kwatra SG. Itch: Pathogenesis and treatment. J Am Acad Dermatol 2022;86(1):17-34. doi: 10.1016/j.jaad.2021.07.078 https://www.jaad.org/article/S0190-9622(21)02635-9/fulltext

Roh YS, Choi J, Sutaria N, Kwatra SG. Itch: Epidemiology, clinical presentation, and diagnostic workup. J Am Acad Dermatol 2022;86(1):1-14. doi: 10.1016/j.jaad.2021.07.076 https://www.jaad.org/article/S0190-9622(21)02369-0/fulltext

Theodosiou G, Nissen T, Weisshaar E, Plachta-Danielzik S, Augustin M, Ständer S, Von Kobyletzki LB, Fölster-Holst R. The Prevalence of Itch in German Schoolchildren: A Population-based Study. Acta Derm Venereol 2022. doi: 10.2340/actadv.v102.1063 (Online ahead of print) https://medicaljournalssweden.se/actadv/article/view/1063

Ofenloch R, Grochulska K, Mettang T, Weisshaar E. The incidence of chronic itch in hemodialysis patients and factors associated. Br J Dermatol 2022. doi: 10.1111/bjd.21024 (Online ahead of print) https://onlinelibrary.wiley.com/doi/10.1111/bjd.21024

Stefaniak AA, Pereira MP, Zeidler C, Ständer S. Pruritus in Pregnancy. Am J Clin Dermatol. 2022;23(2):231-246. doi: 10.1007/s40257-021-00668-7 https://link.springer.com/article/10.1007/s40257-021-00668-7

Topp J, Apfelbacher C, Ständer S, Augustin M, Blome C. Measurement Properties of Patient-Reported Outcome Measures for Pruritus: An Updated Systematic Review. J Invest Dermatol 2022;142(2):343-354. doi: 10.1016/j.jid.2021.06.032 https://www.jidonline.org/article/S0022-202X(21)01498-6/fulltext

2021

Weisshaar E. Itch: A Global Problem? Front Med (Lausanne) 2021; 28;8:665575. doi: 10.3389/fmed.2021.665575 https://www.frontiersin.org/articles/10.3389/fmed.2021.665575/full

Ständer S, Sun YG, Schmelz M. Editorial: Pruritus Medicine. Front Med (Lausanne) 2021;8:763667. doi: 10.3389/fmed.2021.763667
https://www.frontiersin.org/articles/10.3389/fmed.2021.763667/full

Storck M, Sandmann S, Bruland P, Pereira MP, Steinke S, Riepe C, Soto-Rey I, Garcovich S, Augustin M, Blome C, Bobko S, Legat FJ, Potekaev N, Lvov A, Misery L, Weger W, Reich A, Şavk E, Streit M, Serra-Baldrich E, Szepietowski JC, Dugas M, Ständer S, Zeidler C. Pruritus Intensity Scales across Europe: a prospective validation study. J Eur Acad Dermatol Venereol. 2021 May;35(5):1176-1185. doi: 10.1111/jdv.17111 https://onlinelibrary.wiley.com/doi/10.1111/jdv.17111

Takanami K, Uta D, Matsuda KI, Kawata M, Carstens E, Sakamoto T, Sakamoto H. Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons. Proc Natl Acad Sci USA 2021: 118(31):e2103536118. doi: 10.1073/pnas.2103536118
https://www.pnas.org/doi/10.1073/pnas.2103536118

2020

Cevikbas F, Lerner EA. Physiology and Pathophysiology of Itch. Physiol Rev 2020;100(3):945-982. doi: 10.1152/physrev.00017.2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474262/

Buhl T, Ikoma A, Kempkes C, Cevikbas F, Sulk M, Buddenkotte J, Akiyama T, Crumrine D, Camerer E, Carstens E, Schön MP, Elias P, Coughlin SR, Steinhoff M. Protease-Activated Receptor-2 Regulates Neuro-epidermal Communication in Atopic Dermatitis. Front Immunol 2020; 11:1740. doi: 10.3389/fimmu.2020.01740
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01740/full

Domocos D, Selescu T, Ceafalan LC, Iodi Carstens M, Carstens E, Babes A. Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat. J Neurosci Res 2020; 98(10):1999-2017. doi: 10.1002/jnr.24633
https://ucdavis.pure.elsevier.com/en/publications/role-of-5-ht1a-and-5-ht3-receptors-in-serotonergic-activation-of-

2019
 
Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Giménez-Arnau AM, Lambert J, Leslie T, Mettang T, Misery L, Şavk E, Streit M, Tschachler E, Wallengren J, Ständer S. European S2k Guideline on Chronic Pruritus. Acta Derm Venereol. 2019;99(5): 469-506. doi: 10.2340/00015555-3164
https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3164

Yosipovitch G, Misery L, Proksch E, Metz M, Ständer S, Schmelz M. Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Acta Derm Venereol 2019;99(13):1201-1209. doi: 10.2340/00015555-3296 https://medicaljournalssweden.se/actadv/article/view/3439

2018

Carstens E, Carstens MI, Akiyama T, Davoodi A, Nagamine M. Opposing effects of cervical spinal cold block on spinal itch and pain transmission. Itch 2018; 3: e16. doi: 10.1097/itx.0000000000000016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204798/

Pereira MP, Steinke S, Zeidler C, Forner C, Riepe C, Augustin M, Bobko S, Dalgard F, Elberling J, Garcovich S, Gieler U, Gonçalo M, Halvorsen JA, Leslie TA, Metz M, Reich A, Şavk E, Schneider G, Serra-Baldrich E, Ständer HF, Streit M, Wallengren J, Weller K, Wollenberg A, Bruland P, Soto-Rey I, Storck M, Dugas M, Weisshaar E, Szepietowski JC, Legat FJ, Ständer S; EADV Task Force Pruritus group members. European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo.
J Eur Acad Dermatol Venereol. 2018; 32(7): 1059-1065. doi: 10.1111/jdv.14570 https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.14570

Pereira MP, Lüling H, Dieckhöfer A, Steinke S, Zeidler C, Agelopoulos K, Ständer S. Application of an 8% capsaicin patch normalizes epidermal TRPV1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus.
J Eur Acad Dermatol Venereol. 2018; 32(9): 1535-1541. doi: 10.1111/jdv.14857 https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.14857

Steinhoff M, Schmelz M, Szabó IL, Oaklander AL. Clinical presentation, management, and pathophysiology of neuropathic itch.
Lancet Neurol. 2018; 17(8): 709-720. doi: 10.1016/S1474-4422(18)30217-5 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30217-5/fulltext

Yosipovitch G, Ständer S, Kerby MB, Larrick JW, Perlman AJ, Schnipper EF, Zhang X, Tang JY, Luger T, Steinhoff M. Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial.
J Am Acad Dermatol. 2018; 78(5): 882-891.e10. doi: 10.1016/j.jaad.2018.02.030 https://www.jaad.org/article/S0190-9622(18)30315-3/fulltext

Nattkemper LA, Tey HL, Valdes-Rodriguez R, Lee H, Mollanazar NK, Albornoz C, Sanders KM, and Yosipovitch G. The Genetics of Chronic Itch: Gene, Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch.
J Invest Dermatol. 2018; 138: 1311e1317. doi:10.1016/j.jid.2017.12.029 https://www.jidonline.org/article/S0022-202X(18)30004-6/abstract

Fleischer AB Jr. Evaluation of the symptom of itch ambulatory office-based care in the United States.
Itch 2018; 3(2); p e15. doi: 10.1097/itx.0000000000000015 https://journals.lww.com/itch/Fulltext/2018/06000/Evaluation_of_the_symptom_of_itch_ambulatory.4.aspx

2017

Pereira MP, Pogatzki-Zahn E, Snels C, Vu T-H, Üçeyler N, Loser K, Sommer C, Walburga A, Evers M, van Laarhoven AIM, Agelopoulos K, Ständer S. There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations.
Exp Dermatol 2017; 26(10): 969-971. doi: 10.1111/exd.13343 https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13343

2016

Pongcharoen P, Fleischer AB Jr. An evidence-based review of systemic treatments for itch.
Eur J Pain 2016; 20(1): 24-31. doi: 10.1002/ejp.766 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.766" target=_blank

Chen Y, Fang Q, Wang Z, Zhang JY, MacLeod AS, Hall RP, Liedtke WB. Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
J Biol Chem. 2016;291(19):10252-62. http://www.jbc.org/content/291/19/10252.long

Akiyama T, Ivanov M, Nagamine M, Davoodi A, Carstens MI, Ikoma A, Cevikbas F, Kempkes C, Buddenkotte J, Steinhoff M, Carstens E. Involvement of TRPV4 in Serotonin-Evoked Scratching.
J Invest Dermatol. 2016; 136(1):154-60. http://www.sciencedirect.com/science/article/pii/S0022202X15000342

2015

Pongcharoen P, Fleischer AB Jr. An evidence-based review of systemic treatments for itch.
Eur J Pain. 2015 Sep 28. doi: 10.1002 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.766

Michaela E.R. Kopyciok, Hartmut F. Ständer, Nani Osada, Sabine Steinke, Sonja Ständer Prevalence and Characteristics of Pruritus: A One-Week Cross-sectional Study in a German Dermatology Practice
Acta Derm Venereol. 2015;96(1):50-55. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2166

Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. Gate control of mechanical itch by a subpopulation of spinal cord interneurons.
Science. 2015;350(6260):550-4. https://www.sciencemag.org/content/350/6260/550.full

Weiss M, Mettang T, Tschulena U, Passlick-Deetjen J, Weisshaar E. Prevalence of Chronic Itch and Associated Factors in Haemodialysis Patients: A Representative Cross-sectional Study.
Acta Derm Venereol. 2015;95(7):816-21. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2087&html=1

Vierow V, Forster C, Vogelgsang R, Dörfler A, Handwerker HO. Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin.
Acta Derm Venereol. 2015;95(6):645-52. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2006&html=1

Hartmann EM, Handwerker HO, Forster C. Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin.
Acta Derm Venereol. 2015;95(1):25-30. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1894&html=1

Mochizuki H, Papoiu AD, Nattkemper LA, Lin AC, Kraft RA, Coghill RC, Yosipovitch G. Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients.
J Invest Dermatol. 2015;135(11):2814-23. http://www.nature.com/jid/journal/v135/n11/full/jid2015223a.html

Cedeno-Laurent F, Singer EM, Wysocka M, Benoit BM, Vittorio CC, Kim EJ, Yosipovitch G, Rook AH. Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities.
Clin Immunol. 2015;158(1):1-7. http://www.sciencedirect.com/science/article/pii/S1521661615000893

Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P. A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde.
Acta Derm Venereol. 2015 Oct 5;95(7):798-803. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2103&html=1

Roblin D, Yosipovitch G, Boyce B, Robinson J, Sandy J, Mainero V, Wickramasinghe R, Anand U, Anand P. Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis.
Acta Derm Venereol. 2015;95(5):542-8. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2047&html=1

Morita T, McClain SP, Batia LM, Pellegrino M, Wilson SR, Kienzler MA, Lyman K, Olsen AS, Wong JF, Stucky CL, Brem RB, Bautista DM. HTR7 Mediates Serotonergic
Acute and Chronic Itch. Neuron. 2015;87(1):124-38. http://www.sciencedirect.com/science/article/pii/S0896627315004833

Baumbauer KM, DeBerry JJ, Adelman PC, Miller RH, Hachisuka J, Lee KH, Ross SE, Koerber HR, Davis BM, Albers KM. Keratinocytes can modulate and directly initiate nociceptive responses.
Elife. 2015;4. http://elifesciences.org/content/4/e09674

Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.
Nat Commun. 2015;6:7864. http://www.nature.com/ncomms/2015/150728/ncomms8864/full/ncomms8864.html

Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis.
J Pain. 2015;16(8):741-9. http://www.sciencedirect.com/science/article/pii/S152659001500663X

Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis.
Pain. 2015;156(9):1737-46. http://ovidsp.tx.ovid.com/

Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW 4th, Rogers JA. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.
Nat Biotechnol. 2015 Nov 9. http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3415.html

Montgomery KL, Yeh AJ, Ho JS, Tsao V, Mohan Iyer S, Grosenick L, Ferenczi EA, Tanabe Y, Deisseroth K, Delp SL, Poon AS. Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice.
Nat Methods. 2015 Oct;12(10):969-74. http://www.nature.com/nmeth/journal/v12/n10/full/nmeth.3536.html

Akiyama T, Nagamine M, Davoodi A, Iodi Carstens M, Cevikbas F, Steinhoff M, Carstens E. Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse.
J Neurophysiol. 2015;114(4):2528-34. http://jn.physiology.org/content/114/4/2528.long

Akiyama T, Curtis E, Nguyen T, Carstens MI, Carstens E. Anatomical evidence of pruriceptive trigeminothalamic and trigeminoparabrachial projection neurons in mice.
J Comp Neurol. 2015 Jun 23. http://onlinelibrary.wiley.com/doi/10.1002/cne.23839/abstract

Akiyama T, Nguyen T, Curtis E, Nishida K, Devireddy J, Delahanty J, Carstens MI, Carstens E. A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch.
Pain. 2015;156(7):1240-6. http://ovidsp.tx.ovid.com/

Akiyama T, Carstens MI, Piecha D, Steppan S, Carstens E. Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice.
Acta Derm Venereol. 2015;95(2):147-50. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1879

Lipshetz B, Giesler GJ. Effects of scratching and other counter-stimuli on responses of trigeminothalamic tract neurons to itch-inducing stimuli in rats.
  J Neurophysiol. 2015 Nov 4:jn.00326.2015. http://jn.physiology.org/content/early/2015/10/30/jn.00326.2015.long

Foster E, Wildner H, Tudeau L, Haueter S, Ralvenius WT, Jegen M, Johannssen H, Hösli L, Haenraets K, Ghanem A, Conzelmann KK, Bösl M, Zeilhofer HU. Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
Neuron. 2015;85(6):1289-304. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372258/

Jansen NA, Giesler GJ Jr. Response characteristics of pruriceptive and nociceptive trigeminoparabrachial tract neurons in the rat.
J Neurophysiol. 2015;113(1):58-70. http://jn.physiology.org/content/113/1/58.long

2014

Papoiu AD, Emerson NM, Patel TS, Kraft RA, Valdes-Rodriguez R, Nattkemper LA, Coghill RC, Yosipovitch G. Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage renal disease.
J Neurophysiol. 2014 Oct 1;112(7):1729-38. http://jn.physiology.org/content/112/7/1729.long

Moser HR, Giesler GJ Jr. Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats.
Neuroscience. 2014;274:119-27. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100339/

Moser HR, Giesler GJ Jr. Characterization of pruriceptive trigeminothalamic tract neurons in rats.
J Neurophysiol. 2014;111(8):1574-89. http://jn.physiology.org/content/111/8/1574.long

Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI. Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch.
J Clin Invest. 2014;124(8):3612-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109547/

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.
Neuron. 2014;82(3):573-86. http://www.sciencedirect.com/science/article/pii/S0896627314002086

Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.
Brain. 2014;137(Pt 4):1039-50. http://brain.oxfordjournals.org/content/137/4/1039.long

Kido-Nakahara M, Buddenkotte J, Kempkes C, Ikoma A, Cevikbas F, Akiyama T, Nunes F, Seeliger S, Hasdemir B, Mess C, Buhl T, Sulk M, Müller FU, Metze D, Bunnett NW, Bhargava A, Carstens E, Furue M, Steinhoff M. Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
J Clin Invest. 2014;124(6):2683-95. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038561/

Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
J Allergy Clin Immunol. 2014;133(2):448-60. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960328/

Akiyama T, Nagamine M, Carstens MI, Carstens E. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Neuroscience. 2014;266:38-46. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063361/

Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch.
Pain. 2014;155(1):80-92. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947363/

Zhao ZQ, Liu XY, Jeffry J, Karunarathne WK, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L, Wu ZY, Kim S, Huo FQ, Mo P, Barry DM, Zhang CK, Kim JY, Gautam N, Renner KJ, Li YQ, Chen ZF. Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling.
Neuron. 2014;84(4):821-34. http://www.sciencedirect.com/science/article/pii/S0896627314009015

Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE, Li YQ, Chen ZF. Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
J Neurosci. 2014;34(37):12402-14. http://www.jneurosci.org/content/34/37/12402.long

Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ, Chen ZF. B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway.
Mol Pain. 2014;10:4. http://www.molecularpain.com/content/10/1/4

2013

Papoiu AD, Nattkemper LA, Sanders KM, Kraft RA, Chan YH, Coghill RC, Yosipovitch G. Brain's reward circuits mediate itch relief. a functional MRI study of active scratching.
PLoS One. 2013 Dec 6;8(12):e82389. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082389

Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF Jr, Zhong J, Chen ZF. Chronic itch development in sensory neurons requires BRAF signaling pathways.
J Clin Invest. 2013;123(11):4769-80. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809799/

Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G. Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch.
J Invest Dermatol. 2013;133(10):2489-92. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737283/

Mishra SK, Hoon MA. The cells and circuitry for itch responses in mice.
Science. 2013;340(6135):968-71. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670709/

Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
Nat Neurosci. 2013;16(7):910-8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695070/

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch.
Nat Neurosci. 2013;16(2):174-82. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557753/

Wilson SR, Thé L, Batia LM, Beattie K, Katibah GE, McClain SP, Pellegrino M, Estandian DM, Bautista DM. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.
Cell. 2013;155(2):285-95. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041105/

Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, Lumpkin EA, Bautista DM. The ion channel TRPA1 is required for chronic itch.
J Neurosci. 2013;33(22):9283-94. http://www.jneurosci.org/content/33/22/9283.long

Moser HR, Giesler GJ Jr. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
J Neurosci. 2013;33(14):6093-101. http://www.jneurosci.org/content/33/14/6093.long

Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI. Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Neuron. 2013;78(2):312-24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700415/

Schley M, Rukwied R, Blunk J, Menzer C, Konrad C, Dusch M, Schmelz M, Benrath J. Mechano-insensitive nociceptors are sufficient to induce histamine-induced itch.
Acta Derm Venereol. 2013;93(4):394-9. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1513&html=1

Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu AD, Nattkemper LA, Chan YH, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates.
Acta Derm Venereol. 2013;93(1):27-9. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1406&html=1

Stumpf A, Burgmer M, Schneider G, Heuft G, Schmelz M, Phan NQ, Ständer S, Pfleiderer B. Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers.
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2012

Davidson S, Zhang X, Khasabov SG, Moser HR, Honda CN, Simone DA, Giesler GJ Jr. Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate.
J Neurophysiol. 2012;108(6):1711-23. http://jn.physiology.org/content/108/6/1711.long

Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
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Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X. Mechanisms of itch evoked by β-alanine.
J Neurosci. 2012;32(42):14532-7. http://www.jneurosci.org/content/32/42/14532.long

Ma C, Nie H, Gu Q, Sikand P, Lamotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.
J Neurophysiol. 2012;107(1):357-63. http://jn.physiology.org/content/107/1/357.long

Holle H, Warne K, Seth AK, Critchley HD, Ward J. Neural basis of contagious itch and why some people are more prone to it.
Proc Natl Acad Sci U S A. 2012;109(48):19816-21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511754/

2011

Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Nat Neurosci. 2011;14(5):595-602. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181150/

Liu XY, Liu ZC, Sun YG, Ross M, Kim S, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, Chen ZF. Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Cell. 2011;147(2):447-58. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197217/

Sikand P, Dong X, LaMotte RH. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.
J Neurosci. 2011;31(20):7563-7. http://www.jneurosci.org/content/31/20/7563.long

Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, Shim B, LaMotte RH, Meyer RA. A role for nociceptive, myelinated nerve fibers in itch sensation.
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Patel KN, Liu Q, Meeker S, Undem BJ, Dong X. Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
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Sikand P, Shimada SG, Green BG, LaMotte RH. Sensory responses to injection and punctate application of capsaicin and histamine to the skin.
Pain. 2011;152(11):2485-94. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199342/

Sikand P, Dong X, LaMotte RH. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.
J Neurosci. 2011;31(20):7563-7. http://www.jneurosci.org/content/31/20/7563.long

2010

Ständer S, Siepmann D, Herrgott I, Sunderkötter C, Luger TA. Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic
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Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.
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Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
Neuron. 2010;68(3):529-42. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052264/

Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
Neuron. 2010;68(3):543-56. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991105/

Carstens EE, Carstens MI, Simons CT, Jinks SL. Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats.
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2009

Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.
Proc Natl Acad Sci U S A. 2009;106(27):11330-5. http://www.pnas.org/content/106/27/11330.long

Sun YG, Zhao ZQ, Meng XL, Yin J, Liu XY, Chen ZF. Cellular basis of itch sensation.
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Vierow V, Fukuoka M, Ikoma A, Dörfler A, Handwerker HO, Forster C. Cerebral representation of the relief of itch by scratching.
J Neurophysiol. 2009;102(6):3216-24. http://jn.physiology.org/content/102/6/3216.long

Kosteletzky F, Namer B, Forster C, Handwerker HO. Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine.
Acta Derm Venereol. 2009;89(3):271-7. http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-0624&html=1

Davidson S, Zhang X, Khasabov SG, Simone DA, Giesler GJ Jr. Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons.
Nat Neurosci. 2009;12(5):544-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006451/

Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Cell. 2009;139(7):1353-65. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989405/

Sikand P, Shimada SG, Green BG, LaMotte RH. Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
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LaMotte RH, Shimada SG, Green BG, Zelterman D. Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.
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2008

Shimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse.
Pain. 2008;139(3):681-7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723192/

Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, Ringkamp M. A role for polymodal C-fiber afferents in nonhistaminergic itch.
J Neurosci. 2008;28(30):7659-69. http://www.jneurosci.org/content/28/30/7659.long

Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.
J Neurosci. 2008;28(17):4331-5. http://www.jneurosci.org/content/28/17/4331.long

2007

Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, Ringkamp M. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.
J Neurosci. 2007;27(28):7490-7. http://www.jneurosci.org/content/27/28/7490.long

Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ Jr. The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons.
J Neurosci. 2007;27(37):10007-14. http://www.jneurosci.org/content/27/37/10007.long

Sun YG, Chen ZF. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.
Nature. 2007;448(7154):700-3. http://www.nature.com/nature/journal/v448/n7154/full/nature06029.html

2004

Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr. Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
J Neurophysiol. 2004;91(1):213-22. http://jn.physiology.org/content/91/1/213.long

2001

Andrew D, Craig AD. Nat Neurosci.. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.
Nat Neurosci 2001;4(1):72-7. http://www.nature.com/neuro/journal/v4/n1/full/nn0101_72.html

1997

Carstens E. Responses of rat spinal dorsal horn neurons to intracutaneous microinjection of histamine, capsaicin and other irritants. J Neurophysiol 1997;77:2499-2514. doi: 10.1152/jn.1997.77.5.2499 https://journals.physiology.org/doi/full/10.1152/jn.1997.77.5.2499?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE. J Neurosci. Specific C-receptors for itch in human skin. J Neurosci 1997;17(20):8003-8. http://www.jneurosci.org/content/17/20/8003.long